Other conditions
HCQ Study: Investigation of genetic susceptibility to retinal toxicity in patients taking hydroxychloroquine.
Eye condition/Study type:
Subjects taking hydroxychloroquine
Principal Investigator:
Professor Susan Downes
Hydroxychloroquine (HCQ) is commonly used for joint and skin disorders and is being studied for COVID-19 treatment. However, long-term use can cause HCQ retinopathy, leading to irreversible blindness. In the UK, retinal screening for HCQ users is recommended, costing millions annually, but it only detects damage after it occurs. This research aims to use genetic testing to identify patients at risk of retinopathy by comparing the genetic profiles of affected and unaffected individuals. Identifying genetic markers will help develop a screening tool, potentially preventing HCQ retinopathy and reducing the need for costly retinal screenings.
https://studies.ouh.nhs.uk/project_detail/7228/
Currently recruiting. If interested, please contact via email ERGO@ouh.nhs.uk
The MACTEL Study: A Natural History Observation and Registry Study of Macular Telangiectasia Type 2.
Eye condition/Study type:
Macular Telangiectasia Type 2
Principal Investigator:
Miss Samantha de Silva
Macular Telangiectasia (MacTel) type 2 is a retinal disease leading to gradual central vision loss, usually noticeable between ages 40 and 60. This deterioration significantly impacts quality of life, as central vision is crucial for tasks requiring sharp vision, such as reading and driving. MacTel type 2, a bilateral condition, may affect both eyes differently and might be inherited, with 10-20% of patients having affected family members, often asymptomatic. At Oxford Eye Hospital, a secure database will document patient changes from early onset to impairment. Data, shared with the Lowy Medical Research Institute, will support genetic studies, systemic marker investigations, and patient identification for future trials.
https://studies.ouh.nhs.uk/project_detail/4605/
Currently recruiting. If interested, please contact via email ERGO@ouh.nhs.uk
SICKLE EYE PROJECT: Prevalence of visual impairment due to sickle cell retinopathy and maculopathy in the United Kingdom.
Eye condition/Study type:
Sickle cell disease
Principal Investigator:
Professor Susan Downes
This study aims to investigate how sickle cell disease (SCD) affects vision by damaging the retina. Researchers will assess how common vision loss is in SCD patients, how disease severity influences vision, and the impact on quality of life. The study will involve measuring vision and taking retinal images of 600 people with SCD across the UK. Participants will complete a questionnaire about how vision impairment affects daily activities and their experience with eye clinic visits.
https://studies.ouh.nhs.uk/project_detail/9864/
Currently recruiting. If interested, please contact via email ERGO@ouh.nhs.uk